Light-proof drugs generally refer to drugs that need to be stored and used in the dark, because light will accelerate the oxidation of drugs and cause photochemical degradation, which not only reduces the potency of drugs, but also produces color changes and precipitation, which seriously affects the quality of drugs, and even May increase drug toxicity. Light-proof drugs are mainly divided into special-grade light-proof drugs, first-grade light-proof drugs, second-grade light-proof drugs, and third-grade light-proof drugs.
1. Special-grade light-proof drugs: mainly sodium nitroprusside, nifedipine and other drugs, especially sodium nitroprusside, which has poor stability. It is also necessary to use light-proof syringes, infusion tubes, or opaque aluminum foils during infusion administration. If the material is used to wrap the syringe, if the light is decomposed into dark brown, orange or blue substances, it should be disabled at this time;
2. First-class light-avoiding drugs: mainly include fluoroquinolone antibiotics such as levofloxacin hydrochloride and gatifloxacin, as well as drugs such as amphotericin B and doxorubicin. Fluoroquinolone antibiotics need to avoid excessive sunlight exposure and artificial ultraviolet radiation to prevent the occurrence of photosensitivity reactions and toxicity. For example, levofloxacin hydrochloride can cause rare phototoxic reactions (incidence <0.1%). If phototoxic reactions occur, the drug should be discontinued;
3. Secondary light-avoiding drugs: including nimodipine and other antihypertensive drugs, promethazine and other antihistamines, chlorpromazine and other antipsychotic drugs, cisplatin, cyclophosphamide, methotrexate, cytarabine Anti-tumor drugs, as well as water-soluble vitamins, epinephrine, dopamine, morphine and other drugs, need to be stored in the dark and quickly dispensed to prevent oxidation and hydrolysis;
4. Tertiary light shielding drugs: such as fat-soluble vitamins, methylcobalamin, hydrocortisone, prednisone, furosemide, reserpine, procaine hydrochloride, pantoprazole sodium, etoposide, Drugs such as docetaxel, ondansetron, and nitroglycerin are all sensitive to light and are also recommended to be stored in the dark.
Post time: Sep-05-2022